IGF-1 LR3

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 0.1 mg per vial
SKU: IGL01

Product Overview

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a modified analog of endogenous IGF-1 engineered with two key changes: an arginine-3 substitution (replacing the native glutamate) and a 13 amino acid N-terminal extension. These modifications dramatically reduce binding affinity to IGF-binding proteins (IGFBPs 1–6), which normally act as transport and regulatory proteins for IGF-1 in circulation.

By reducing IGFBP binding, IGF-1 LR3 remains in its free, biologically active form significantly longer than native IGF-1, with an estimated half-life of 20–30 hours compared to ~12 minutes for native IGF-1. This extended activity makes it a powerful tool for studying the IGF-1 receptor (IGF-1R) signaling axis, cellular proliferation, differentiation, and anabolic metabolism in research settings.

Research Applications

IGF-1 LR3 has been examined in experimental studies related to:

• IGF-1 receptor (IGF-1R) signaling and AKT/mTOR pathway studies
• Protein synthesis, nitrogen retention, and anabolic metabolism research
• Reduced IGFBP binding and extended half-life pharmacokinetic research
• Cell proliferation, differentiation, and anti-apoptotic signaling
• Muscle satellite cell activation and myogenesis studies
• Comparison with native IGF-1 and IGF-1 DES(1-3) variants

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.