{"product_id":"ae1-ace-031","title":"AE1 ACE-031","description":"\u003cdiv style=\"font-family:Arial,sans-serif;max-width:680px;margin:20px 0 24px;border:1px solid #cbd5e1;border-radius:10px;overflow:hidden;\"\u003e\n\u003cdiv style=\"background:#1a3c5e;color:#fff;padding:12px 16px;\"\u003e\n\u003cstrong style=\"font-size:15px;\"\u003eProtocolo de Dosificación\u003c\/strong\u003e\u003cspan style=\"font-size:12px;margin-left:12px;opacity:0.85;\"\u003e1 vez por semana · Subcutáneo\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"background:#e8f0f8;padding:10px 16px;font-size:13px;color:#1a3c5e;\"\u003e\n\u003cstrong\u003eReconstitución:\u003c\/strong\u003e 1 mg + 1 mL BAC Water = 1 mg\/mL\u003c\/div\u003e\n\u003ctable style=\"width:100%;border-collapse:collapse;font-size:13px;\"\u003e\n\u003cthead\u003e\u003ctr style=\"background:#2d5a8e;color:#fff;\"\u003e\n\u003cth style=\"padding:8px 10px;text-align:left;\"\u003eFase\u003c\/th\u003e\n\u003cth style=\"padding:8px 10px;text-align:left;\"\u003eDosis\u003c\/th\u003e\n\u003cth style=\"padding:8px 10px;text-align:center;\"\u003eUnidades (U-100)\u003c\/th\u003e\n\u003cth style=\"padding:8px 10px;text-align:center;\"\u003eVolumen (mL)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"background:#f8fafc\"\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;\"\u003eEstándar\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;font-weight:600;color:#1a3c5e;\"\u003e0.1 mg\/semana\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;text-align:center;\"\u003e10 unidades\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;text-align:center;\"\u003e0.10 mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"background:#ffffff\"\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;\"\u003eAvanzado\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;font-weight:600;color:#1a3c5e;\"\u003e0.3 mg\/semana\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;text-align:center;\"\u003e30 unidades\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;text-align:center;\"\u003e0.30 mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv style=\"background:#f8fafc;padding:8px 16px;font-size:11px;color:#64748b;\"\u003e⚠️ Solo para investigación. Consulta a un profesional de salud calificado antes de uso.\u003c\/div\u003e\n\u003c\/div\u003e\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥99% HPLC\u003cbr\u003e\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eQuantity:\u003c\/strong\u003e 1 mg per vial\u003cbr\u003e\u003cstrong\u003eSKU:\u003c\/strong\u003e AE1\u003c\/p\u003e\u003ch2\u003eProduct Overview\u003c\/h2\u003e\u003cp\u003eACE-031 is a soluble decoy receptor fusion protein constructed from the extracellular ligand-binding domain of Activin Receptor Type IIB (ActRIIB) fused to the Fc region of human IgG1. The ActRIIB ectodomain has nanomolar affinity for multiple TGF-β superfamily ligands that negatively regulate muscle mass, most notably myostatin (GDF-8), activin A, GDF-11, and BMP-9.\u003c\/p\u003e\n\u003cp\u003eBy sequestering these ligands before they can engage cell-surface ActRIIB receptors and activate the SMAD2\/3 signaling pathway, ACE-031 effectively removes the brakes on muscle protein synthesis, resulting in significant increases in lean muscle mass. In Phase I\/II clinical trials in healthy volunteers, ACE-031 produced dose-dependent increases in thigh muscle volume within weeks of administration. It has been studied in Duchenne muscular dystrophy, cancer cachexia, and other muscle-wasting conditions.\u003c\/p\u003e\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cp\u003eAE1 ACE-031 has been examined in experimental studies related to:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eActRIIB ligand trap pharmacology and myostatin\/activin sequestration\u003c\/li\u003e\n\u003cli\u003eLean muscle mass anabolism and anti-catabolic signaling research\u003c\/li\u003e\n\u003cli\u003eTGF-β superfamily SMAD2\/3 pathway inhibition studies\u003c\/li\u003e\n\u003cli\u003eMuscular dystrophy and cachexia preclinical models\u003c\/li\u003e\n\u003cli\u003eSkeletal muscle hypertrophy mechanisms and satellite cell activation\u003c\/li\u003e\n\u003cli\u003eComparison with anti-myostatin antibodies and other muscle-building biologics\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eHandling and Storage (Laboratory Guidance)\u003c\/h2\u003e\n\u003cp\u003eThis product is supplied as a lyophilized peptide powder.\u003c\/p\u003e\n\u003cp\u003eTypical laboratory handling recommendations include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStore at 2–8 °C upon receipt.\u003c\/li\u003e\n\u003cli\u003eProtect from heat, moisture, and direct light.\u003c\/li\u003e\n\u003cli\u003eAvoid excessive agitation of the solution to maintain peptide stability.\u003c\/li\u003e\n\u003cli\u003eReconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.\u003c\/li\u003e\n\u003cli\u003eUse of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eFor reconstitution, \u003ca href=\"https:\/\/mvlabs.mx\/pages\/calculadora-de-peptidos\" target=\"_blank\"\u003eCLICK HERE to use the PEPTIDE CALCULATOR\u003c\/a\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLaboratory protocols may vary depending on the specific research application.\u003c\/p\u003e\u003ch2\u003eQuality Information\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eResearch grade material\u003c\/li\u003e\n\u003cli\u003eHigh purity (≥99%)\u003c\/li\u003e\n\u003cli\u003eLyophilized for stability\u003c\/li\u003e\n\u003cli\u003eIntended for controlled laboratory environments\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDocumentation such as analytical data or certificates of analysis may be available depending on the supplier.\u003c\/p\u003e\u003ch2\u003eImportant Disclaimer – Research Use Only\u003c\/h2\u003e\n\u003cp\u003eThis product is provided strictly for laboratory research and analytical purposes.\u003c\/p\u003e\n\u003cp\u003eIt is not intended for human or animal consumption.\u003c\/p\u003e\n\u003cp\u003eThis compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.\u003c\/p\u003e\n\u003cp\u003eThe purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.\u003c\/p\u003e","brand":"MV Labs","offers":[{"title":"1 mg","offer_id":44510490853491,"sku":"AE1","price":1000.0,"currency_code":"MXN","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0697\/3577\/6371\/files\/AE1ACEDetail.png?v=1775068048","url":"https:\/\/mvlabs.mx\/products\/ae1-ace-031","provider":"MV Labs","version":"1.0","type":"link"}