{"product_id":"fox04-dri","title":"FOX04-DRI","description":"\u003cdiv style=\"font-family:Arial,sans-serif;max-width:680px;margin:20px 0 24px;border:1px solid #cbd5e1;border-radius:10px;overflow:hidden;\"\u003e\n\u003cdiv style=\"background:#1a3c5e;color:#fff;padding:12px 16px;\"\u003e\n\u003cstrong style=\"font-size:15px;\"\u003eProtocolo de Dosificación\u003c\/strong\u003e\u003cspan style=\"font-size:12px;margin-left:12px;opacity:0.85;\"\u003e3 veces por semana × 1 semana · Subcutáneo\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"background:#e8f0f8;padding:10px 16px;font-size:13px;color:#1a3c5e;\"\u003e\n\u003cstrong\u003eReconstitución:\u003c\/strong\u003e 1 mg + 1 mL BAC Water = 1 mg\/mL\u003c\/div\u003e\n\u003ctable style=\"width:100%;border-collapse:collapse;font-size:13px;\"\u003e\n\u003cthead\u003e\u003ctr style=\"background:#2d5a8e;color:#fff;\"\u003e\n\u003cth style=\"padding:8px 10px;text-align:left;\"\u003eFase\u003c\/th\u003e\n\u003cth style=\"padding:8px 10px;text-align:left;\"\u003eDosis\u003c\/th\u003e\n\u003cth style=\"padding:8px 10px;text-align:center;\"\u003eUnidades (U-100)\u003c\/th\u003e\n\u003cth style=\"padding:8px 10px;text-align:center;\"\u003eVolumen (mL)\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr style=\"background:#f8fafc\"\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;\"\u003eDosis estándar\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;font-weight:600;color:#1a3c5e;\"\u003e1 mg × 3\/semana\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;text-align:center;\"\u003e100 unidades\u003c\/td\u003e\n\u003ctd style=\"padding:8px 10px;border-bottom:1px solid #e2e8f0;text-align:center;\"\u003e1.00 mL\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv style=\"background:#f8fafc;padding:8px 16px;font-size:11px;color:#64748b;\"\u003e⚠️ Solo para investigación. Consulta a un profesional de salud calificado antes de uso.\u003c\/div\u003e\n\u003c\/div\u003e\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥99% HPLC\u003cbr\u003e\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eQuantity:\u003c\/strong\u003e 10 mg per vial\u003cbr\u003e\u003cstrong\u003eSKU:\u003c\/strong\u003e FOX04DRI\u003c\/p\u003e\u003ch2\u003eProduct Overview\u003c\/h2\u003e\u003cp\u003eFOXO4-DRI is a retro-inverso D-amino acid peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53 specifically in senescent cells. In normal physiology, senescent cells upregulate FOXO4, which sequesters p53 in the nucleus and prevents it from triggering apoptosis — effectively allowing senescent cells to persist and contribute to the senescence-associated secretory phenotype (SASP).\u003c\/p\u003e\n\u003cp\u003eThe FOXO4-DRI peptide competitively disrupts this FOXO4–p53 interaction, freeing p53 to translocate to mitochondria and initiate apoptosis selectively in senescent cells. Critically, healthy proliferating cells, which have low FOXO4 expression, are largely spared. This selectivity makes FOXO4-DRI one of the most mechanistically specific senolytic compounds studied to date, with published research demonstrating improved physical function and fur coat restoration in aging mice.\u003c\/p\u003e\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cp\u003eFOX04-DRI has been examined in experimental studies related to:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eSenescent cell clearance (senolytic) mechanism research\u003c\/li\u003e\n\u003cli\u003eFOXO4–p53 protein-protein interaction disruption studies\u003c\/li\u003e\n\u003cli\u003eSenescence-associated secretory phenotype (SASP) suppression models\u003c\/li\u003e\n\u003cli\u003ep53-mediated mitochondrial apoptosis pathway research\u003c\/li\u003e\n\u003cli\u003eAge-related pathology reversal and tissue rejuvenation models\u003c\/li\u003e\n\u003cli\u003eComparison with other senolytics (navitoclax, dasatinib+quercetin)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eHandling and Storage (Laboratory Guidance)\u003c\/h2\u003e\n\u003cp\u003eThis product is supplied as a lyophilized peptide powder.\u003c\/p\u003e\n\u003cp\u003eTypical laboratory handling recommendations include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStore at 2–8 °C upon receipt.\u003c\/li\u003e\n\u003cli\u003eProtect from heat, moisture, and direct light.\u003c\/li\u003e\n\u003cli\u003eAvoid excessive agitation of the solution to maintain peptide stability.\u003c\/li\u003e\n\u003cli\u003eReconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.\u003c\/li\u003e\n\u003cli\u003eUse of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eFor reconstitution, \u003ca href=\"https:\/\/mvlabs.mx\/pages\/calculadora-de-peptidos\" target=\"_blank\"\u003eCLICK HERE to use the PEPTIDE CALCULATOR\u003c\/a\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLaboratory protocols may vary depending on the specific research application.\u003c\/p\u003e\u003ch2\u003eQuality Information\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eResearch grade material\u003c\/li\u003e\n\u003cli\u003eHigh purity (≥99%)\u003c\/li\u003e\n\u003cli\u003eLyophilized for stability\u003c\/li\u003e\n\u003cli\u003eIntended for controlled laboratory environments\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDocumentation such as analytical data or certificates of analysis may be available depending on the supplier.\u003c\/p\u003e\u003ch2\u003eImportant Disclaimer – Research Use Only\u003c\/h2\u003e\n\u003cp\u003eThis product is provided strictly for laboratory research and analytical purposes.\u003c\/p\u003e\n\u003cp\u003eIt is not intended for human or animal consumption.\u003c\/p\u003e\n\u003cp\u003eThis compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.\u003c\/p\u003e\n\u003cp\u003eThe purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.\u003c\/p\u003e","brand":"MV Labs","offers":[{"title":"10 mg","offer_id":44510489641075,"sku":"FOX04DRI","price":10900.0,"currency_code":"MXN","in_stock":false}],"url":"https:\/\/mvlabs.mx\/products\/fox04-dri","provider":"MV Labs","version":"1.0","type":"link"}