5-Amino-1MQ

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 5 mg per vial
SKU: 5AM

Product Overview

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a selective small-molecule inhibitor of NNMT (Nicotinamide N-methyltransferase), an enzyme highly expressed in adipose tissue that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH) as products.

By inhibiting NNMT, 5-Amino-1MQ conserves both NAD+ precursor availability (preventing nicotinamide consumption) and SAM (preventing methylation capacity depletion), effectively reversing the epigenetic and metabolic reprogramming that drives adipogenesis and obesity. Preclinical studies have demonstrated significant reductions in fat mass, adipocyte size, and weight gain without caloric restriction, making it a novel research tool for studying NNMT-mediated epigenetic control of metabolic disease.

Research Applications

5-Amino-1MQ has been examined in experimental studies related to:

• NNMT enzyme inhibition kinetics and selectivity studies
• NAD+ precursor conservation and sirtuin pathway research
• SAM/SAH methylation capacity and epigenetic reprogramming
• Adipogenesis reduction and adipocyte differentiation research
• Metabolic disease without caloric restriction models
• NNMT expression in adipose tissue and metabolic syndrome research

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.