Adipotide

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: APE10

Product Overview

Adipotide (CKGGRAKDC-GG-D(KLAKLAK)2) is a chimeric peptidomimetic consisting of two functional domains connected by a GG linker: a targeting domain (CKGGRAKDC) that binds prohibitin on the vascular endothelium of white adipose tissue blood vessels, and a pro-apoptotic effector domain (D(KLAKLAK)2) — an amphipathic D-amino acid sequence that disrupts mitochondrial membranes upon cell internalization.

The targeting domain exploits the differential expression of prohibitin on adipose vasculature versus other tissues, enabling relatively selective delivery of the mitochondria-disrupting effector domain to fat-feeding blood vessels. Apoptosis of adipose vasculature leads to reduced blood supply and secondary adipocyte death. In published non-human primate studies, adipotide produced significant decreases in body weight (11%) and abdominal fat (27%) without general systemic toxicity, representing a research model for targeted white adipose tissue ablation.

Research Applications

Adipotide has been examined in experimental studies related to:

• Prohibitin-targeted peptide drug delivery to adipose vasculature
• White adipose tissue vasculature ablation and adipocyte death models
• Mitochondria-disrupting D(KLAKLAK)2 effector domain studies
• Targeted fat tissue reduction without systemic toxicity research
• Adipose tissue biology and vascular supply dependency
• Chimeric targeting/effector peptide design pharmacology

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.