DSIP

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: DS10

Product Overview

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from the cerebral venous blood of rabbits in EEG-defined delta-wave sleep states by the Monnier group in 1977. Despite its name, its functions extend well beyond simple sleep induction.

DSIP demonstrates the ability to cross the blood-brain barrier and has been shown to modulate the secretion of multiple anterior pituitary hormones including LH, GH, and ACTH, suggesting a role in neuroendocrine regulation beyond sleep architecture. It also demonstrates antioxidant properties and stress-response attenuation in preclinical models. Its amphiphilic structure and blood-brain barrier permeability make it a research model for CNS-penetrant peptide delivery.

Research Applications

DSIP has been examined in experimental studies related to:

• Sleep architecture modulation and delta wave induction studies
• Neuroendocrine axis (LH, GH, ACTH) modulation research
• Stress response attenuation and cortisol regulation models
• Antioxidant activity and oxidative stress protection in neural tissue
• Blood-brain barrier permeant peptide research
• DSIP receptor characterization and binding studies

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.