Epithalon

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: ET10

Product Overview

Epithalon (also spelled Epitalon; tetrapeptide Ala-Glu-Asp-Gly) is a synthetic tetrapeptide derived from Epithalamin, a polypeptide extract from the bovine pineal gland, developed through research initiated by Professor Vladimir Khavinson's group at the Institute of Gerontology in St. Petersburg, Russia.

Epithalon is studied as a telomerase activator — research suggests it may upregulate telomerase (hTERT) expression, potentially lengthening critically shortened telomeres in somatic cells. Additional research has explored its effects on pineal gland function and melatonin synthesis regulation, antioxidant activity, and epigenetic modulation of gene expression in aging cells. It is one of the most widely referenced peptides in longevity and anti-aging research literature.

Research Applications

Epithalon has been examined in experimental studies related to:

• Telomerase (hTERT) activation and telomere length modulation studies
• Pineal gland function and melatonin synthesis regulation research
• Epigenetic age and gene expression modulation in senescent cells
• Oxidative stress reduction and antioxidant activity research
• Longevity, healthspan, and cellular aging models
• Comparison with other telomerase activators (TA-65, cycloastragenol)

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.