Gonadorelin

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 2 mg per vial
SKU: GnRH2

Product Overview

Gonadorelin is a synthetic decapeptide (Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) that is chemically and biologically identical to endogenous gonadotropin-releasing hormone (GnRH), the primary hypothalamic releasing factor for the reproductive axis. Under physiological conditions, GnRH is secreted in discrete pulses (every 60–120 minutes) by hypothalamic kisspeptin-responsive GnRH neurons.

The pulsatile nature of GnRH secretion is critical for maintaining normal reproductive function — continuous GnRH stimulation desensitizes pituitary GnRH receptors and paradoxically suppresses LH and FSH secretion (exploited therapeutically in GnRH agonist therapies for prostate cancer and endometriosis). Research applications include HPG axis pharmacology, fertility studies, gonadotropin dynamics, and testosterone recovery research.

Research Applications

Gonadorelin has been examined in experimental studies related to:

• Pulsatile GnRH signaling and GnRH receptor pharmacology
• LH and FSH secretion dynamics and HPG axis regulation research
• Reproductive endocrinology and fertility models
• Continuous vs pulsatile GnRH stimulation pharmacology studies
• Testosterone recovery and hypogonadism research models
• GnRH receptor desensitization and downregulation mechanisms

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.