Mots-c

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: MS10

Product Overview

MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c) is a 16-amino acid mitochondria-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome — making it one of a rare class of peptides encoded by mitochondrial rather than nuclear DNA.

MOTS-c acts as a metabolic regulator through AMPK (AMP-activated protein kinase) activation, enhancing glucose uptake in skeletal muscle, improving insulin sensitivity, and promoting mitochondrial homeostasis. Remarkably, plasma MOTS-c levels have been found to be significantly higher in long-lived individuals in human studies, and exercise increases MOTS-c production, suggesting it may function as a mitokine mediating exercise-related metabolic benefits.

Research Applications

Mots-c has been examined in experimental studies related to:

• Mitochondria-derived peptide (MDP) signaling and biology
• AMPK activation and skeletal muscle glucose uptake studies
• Exercise mimicry and endurance metabolism research
• Insulin sensitivity and metabolic disease models
• Mitokine signaling between mitochondria and systemic tissues
• Aging and longevity biomarker research

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.