Tirzepatide
Tirzepatide
The first dual GLP-1/GIP agonist. SURMOUNT-1 Phase 3 showed up to 22.5% mean weight loss — surpassing any previous weight pharmacotherapy. Available for research in Mexico.
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Mechanism of Action
GLP-1/GIP Dual Agonist · SURMOUNT Trials
Tirzepatide is a 39-aa peptide with balanced agonism at GLP-1R and GIPR. GIP co-agonism potentiates GLP-1-mediated satiety while reducing nausea, enabling dose escalation to levels not tolerable with GLP-1 alone. Dual mechanism enhances appetite reduction, insulin sensitivity, and adipose remodeling.[1]
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Clinical Evidence
Published research data
SURMOUNT-1 (Jastreboff et al., NEJM 2022): N=2,539, 72 weeks.[1]
- 15 mg/week: −22.5% mean weight loss
- 10 mg: −19.5% · 5 mg: −15.0%
- FDA approved as Zepbound® (Nov 2023)
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Research Dosing Protocol
⚠ Research reference only — not medical advice
Reconstitution
| Phase | Dose | Units (U-100) | Volume | Notes |
|---|---|---|---|---|
| Weeks 1–4 | 2.5 mg | 50 U | 0.50 mL | Starting |
| Weeks 5–8 | 5 mg | 100 U | 1.00 mL | Per tolerance |
| Weeks 9–12 | 7.5 mg | 150 U* | 1.50 mL* | Per tolerance |
| Weeks 13–16 | 10 mg | 200 U* | 2.00 mL* | Per tolerance |
| Weeks 17+ | 15 mg | 300 U* | 3.00 mL* | Max · *use 3mL syringe |
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Safety Profile
Adverse event reference
- Nausea (~31%), diarrhea (~23%) — milder than semaglutide due to GIP co-agonism
- Discontinuation: 4.3% at 15mg
- Pancreatitis: rare; monitor
References
- Jastreboff AM et al. Tirzepatide Once Weekly for the Treatment of Obesity. NEJM 2022;387:205–216. DOI
© 2026 MVLabs.mx · Tirzepatide México · Zepbound México investigación · GLP-1 GIP México · Peptide Calculator
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Seguridad garantizada
Este producto cumple con los más altos estándares de seguridad y calidad.
- Certificación de calidad internacional
- Materiales no tóxicos y seguros
- Probado en laboratorios certificados
- Garantía de satisfacción 100%