AE1 ACE-031

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 1 mg per vial
SKU: AE1

Product Overview

ACE-031 is a soluble decoy receptor fusion protein constructed from the extracellular ligand-binding domain of Activin Receptor Type IIB (ActRIIB) fused to the Fc region of human IgG1. The ActRIIB ectodomain has nanomolar affinity for multiple TGF-β superfamily ligands that negatively regulate muscle mass, most notably myostatin (GDF-8), activin A, GDF-11, and BMP-9.

By sequestering these ligands before they can engage cell-surface ActRIIB receptors and activate the SMAD2/3 signaling pathway, ACE-031 effectively removes the brakes on muscle protein synthesis, resulting in significant increases in lean muscle mass. In Phase I/II clinical trials in healthy volunteers, ACE-031 produced dose-dependent increases in thigh muscle volume within weeks of administration. It has been studied in Duchenne muscular dystrophy, cancer cachexia, and other muscle-wasting conditions.

Research Applications

AE1 ACE-031 has been examined in experimental studies related to:

• ActRIIB ligand trap pharmacology and myostatin/activin sequestration
• Lean muscle mass anabolism and anti-catabolic signaling research
• TGF-β superfamily SMAD2/3 pathway inhibition studies
• Muscular dystrophy and cachexia preclinical models
• Skeletal muscle hypertrophy mechanisms and satellite cell activation
• Comparison with anti-myostatin antibodies and other muscle-building biologics

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.