AICAR

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 50 mg per vial
SKU: AR50

Product Overview

AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is a cell-permeable nucleoside analog that is phosphorylated intracellularly by adenosine kinase to AICA-ribotide (ZMP). ZMP is a structural analog of AMP that directly activates AMPK (AMP-activated protein kinase) by mimicking the signal of low cellular energy status.

AMPK activation by AICAR/ZMP triggers a coordinated metabolic reprogramming: upregulating fatty acid beta-oxidation, glucose transporter GLUT4 expression, and mitochondrial biogenesis while simultaneously suppressing fatty acid synthesis, gluconeogenesis, and protein synthesis. Because of these effects, AICAR has been extensively studied as an exercise mimetic, particularly in sedentary animal models where it replicates some molecular adaptations of endurance training.

Research Applications

AICAR has been examined in experimental studies related to:

• AMPK activation via ZMP and AMP-mimicking signaling studies
• Fatty acid beta-oxidation and energy substrate utilization research
• Exercise mimicry and endurance physiology models
• GLUT4 upregulation and skeletal muscle glucose uptake studies
• Mitochondrial biogenesis (PGC-1α) stimulation research
• Gluconeogenesis suppression and hepatic glucose metabolism

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.