FOX04-DRI

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: FOX04DRI

Product Overview

FOXO4-DRI is a retro-inverso D-amino acid peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53 specifically in senescent cells. In normal physiology, senescent cells upregulate FOXO4, which sequesters p53 in the nucleus and prevents it from triggering apoptosis — effectively allowing senescent cells to persist and contribute to the senescence-associated secretory phenotype (SASP).

The FOXO4-DRI peptide competitively disrupts this FOXO4–p53 interaction, freeing p53 to translocate to mitochondria and initiate apoptosis selectively in senescent cells. Critically, healthy proliferating cells, which have low FOXO4 expression, are largely spared. This selectivity makes FOXO4-DRI one of the most mechanistically specific senolytic compounds studied to date, with published research demonstrating improved physical function and fur coat restoration in aging mice.

Research Applications

FOX04-DRI has been examined in experimental studies related to:

• Senescent cell clearance (senolytic) mechanism research
• FOXO4–p53 protein-protein interaction disruption studies
• Senescence-associated secretory phenotype (SASP) suppression models
• p53-mediated mitochondrial apoptosis pathway research
• Age-related pathology reversal and tissue rejuvenation models
• Comparison with other senolytics (navitoclax, dasatinib+quercetin)

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.