LL37

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 5 mg per vial
SKU: LL37-5

Product Overview

LL37 is a 37-amino acid cationic amphipathic alpha-helical antimicrobial peptide constituting the C-terminal domain of the human cathelicidin precursor protein hCAP18 (human cationic antimicrobial protein 18). It is the only cathelicidin peptide expressed in humans and represents a critical first-line effector of innate immune defense against bacteria, fungi, viruses, and protozoa.

LL37 exerts antimicrobial activity primarily through membrane disruption — its amphipathic helix inserts into microbial lipid bilayers at an angle, inducing pore formation or membrane fragmentation through toroidal pore or carpet mechanisms. Beyond direct antimicrobial activity, LL37 modulates immune responses by binding to LPS (reducing endotoxin activity), activating TLR4, recruiting neutrophils and dendritic cells, promoting wound healing through keratinocyte migration, and inducing autophagy in infected cells. Research also examines its complex, context-dependent roles in cancer biology.

Research Applications

LL37 has been examined in experimental studies related to:

• Amphipathic helix antimicrobial membrane disruption mechanism studies
• LPS binding and endotoxin neutralization research
• TLR4 signaling and innate immune cell recruitment studies
• Keratinocyte migration, wound healing, and re-epithelialization research
• Antiviral activity and viral membrane disruption pharmacology
• LL37 in cancer biology: pro- and anti-tumor activity research

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.