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98.7% HPLC
Retatrutide
Péptido

Retatrutide

★★★★★ 4.9 · In stock
$ 6,900.00$ 9,200.00 -25%
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5mg $ 1,500.00
10mg $ 2,800.00
30mg $ 6,900.00
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Description +

 

Purity ≥98.7% HPLC Format Lyophilized powder 10 mg / vial SKU RT10 Research use only

Studied across metabolic and energy-balance pathways.

Overview

Retatrutide is an investigational peptide studied in metabolic research. It is designed as a triple receptor agonist, interacting simultaneously with three key pathways of metabolic regulation: the GLP-1 receptor (glucagon-like peptide-1), the GIP receptor (glucose-dependent insulinotropic polypeptide) and the glucagon receptor. Because it engages all three at once, it is described in the literature as a "triple agonist." It remains under clinical investigation and is not approved as a pharmaceutical product.

Research applications

  • Metabolic regulation and energy-balance mechanisms
  • Glucose homeostasis and insulin secretion research
  • Appetite and satiety signaling pathway studies
  • Obesity and metabolic-disorder research models
  • Triple-agonist pharmacology vs. single/dual GLP-1/GIP compounds

Comparative research data

In published clinical research, retatrutide produced the largest mean body-weight reduction among the leading incretin-based compounds. Figures below come from separate trials (not head-to-head):

Retatrutide12 mg · 48 wk

~24%
Tirzepatide15 mg · 72 wk

~22.5%
Semaglutide2.4 mg · 68 wk

~15%

Research dosing reference

Example weekly escalation in 2-week steps, with draw volumes for a 10 mg vial reconstituted in 2 mL bacteriostatic water (5 mg/mL). Adjust any volume with the calculator. Dose levels up to 12 mg were evaluated in the phase-2 trial.

Week Weekly dose Volume @5 mg/mL U-100 units
1–2 0.5 mg 0.10 mL 10 u
3–4 1 mg 0.20 mL 20 u
5–6 1.5 mg 0.30 mL 30 u
7–8 2 mg 0.40 mL 40 u
9–10 3 mg 0.60 mL 60 u
11–12 4 mg 0.80 mL 80 u
13+ 4–8 mg 0.80–1.60 mL 80–160 u

Illustrative escalation for research reference only — not dosing guidance for human use. Levels up to 12 mg were studied (Jastreboff et al., 2023). Use the calculator for other vial sizes or reconstitution volumes.

Community note: Informal reports from fitness and research-oriented communities suggest that some users experiment with lower-dose, maintenance-style approaches rather than increasing toward the upper ranges evaluated in clinical studies. Ranges around 1–2 mg weekly are commonly mentioned anecdotally; however, these reports are not clinical evidence and should not be interpreted as dosing guidance, a standardized protocol, or confirmation of long-term safety.

Open the peptide calculator →

Handling & storage

Supplied as a lyophilized powder. Store at 2–8 °C on receipt; protect from heat, light and moisture, and avoid excessive agitation. If reconstitution is required for laboratory work, use sterile technique — bacteriostatic water, or 0.6% acetic acid for low-solubility peptides. Protocols vary by research application.

References

  • Jastreboff AM, Kaplan LM, Frías JP, et al. Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. N Engl J Med. 2023;389(6):514–526. nejm.org
  • Coskun T, Urva S, Roell WC, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept. Cell Metab. 2022;34(9):1234–1247. cell.com
  • Urva S, Coskun T, Loh MT, et al. LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b trial. Lancet. 2022;400(10366):1869–1881. thelancet.com
Research use only. Research-grade, high-purity material (≥98.7% HPLC) supplied strictly for laboratory and analytical purposes. Not for human or animal consumption; not a drug or dietary supplement; not approved by the FDA, EMA or other agencies. To be handled only by qualified professionals in appropriate facilities, under all applicable laws. A certificate of analysis may be available on request.
Specifications +
Purity (HPLC)≥ 98.7%
FormLyophilized
CategoryPéptido
Storage-20 °C, no light
SKU8209021730931
Reconstitution +
Reconstitute with bacteriostatic water and use our reconstitution calculator to convert your target dose into syringe units.
Certificate (COA) +
Each batch includes a verifiable certificate of analysis at /verify using the product code.
Tool

Reconstitution & dosing calculator

Convert your target dose into syringe units for this compound, on its dedicated page.

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Academy

Guides & articles

⚠ Solo para investigación (RUO). Compuesto liofilizado de grado investigación para uso in vitro únicamente. No aprobado para uso humano o veterinario. Venta a investigadores calificados. +18.