SS-31

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: 2S10

Product Overview

SS-31 (Szeto-Schiller peptide 31, also known by its INN Elamipretide, with the sequence D-Arg-dimethylTyr-Lys-Phe-NH2) is a cell-permeable, mitochondria-targeted tetrapeptide that selectively concentrates within the inner mitochondrial membrane (IMM) at approximately 1000-fold higher concentrations than in the cytoplasm.

Its primary mechanism involves binding to cardiolipin — an anionic phospholipid unique to the IMM — stabilizing mitochondrial cristae architecture and the electron transport chain (ETC) supercomplexes. This prevents cardiolipin peroxidation, reduces mitochondrial ROS generation, and maintains cytochrome c in its electron-carrier role rather than apoptotic trigger. SS-31 has been studied in cardiac ischemia-reperfusion injury, heart failure, neurodegenerative disease, and age-related mitochondrial dysfunction models.

Research Applications

SS-31 has been examined in experimental studies related to:

• Cardiolipin binding and inner mitochondrial membrane stabilization
• Electron transport chain supercomplex preservation research
• ROS reduction and mitochondrial oxidative stress protection
• Cardiac ischemia-reperfusion injury models
• Heart failure and mitochondrial dysfunction research
• Age-related mitochondrial decline and bioenergetics studies

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.