SLU-PP-332

SLU-PP-332 (a.k.a. SLU-PP-332) is a potent synthetic pan-agonist of Estrogen-Related Receptors alpha, beta, and gamma (ERRα/β/γ) — orphan nuclear receptors in the nuclear receptor superfamily that lack known endogenous ligands but play critical roles in regulating oxidative metabolism, mitochondrial biogenesis, and energy homeostasis in high-energy tissues including heart, skeletal muscle, and brown adipose tissue.

SLU-PP-332 binds to and activates all three ERR isoforms simultaneously, triggering transcriptional programs that upregulate PGC-1α-dependent mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation pathways. In preclinical studies, SLU-PP-332 produced remarkable exercise-mimetic effects including significant increases in running endurance (70% improvement in mice) and demonstrated therapeutic potential in heart failure models by restoring cardiac metabolic function and reducing pathological cardiac remodeling.

• ERRα/β/γ nuclear receptor pan-agonism and transcriptional studies
• PGC-1α upregulation and mitochondrial biogenesis research
• Exercise mimicry and endurance performance models
• Heart failure metabolic rescue and cardiac remodeling studies
• Fatty acid oxidation and oxidative phosphorylation in muscle research
• Comparison with other nuclear receptor agonists (PPARs, LXR)

Dose levels referenced by the MVLabs peptide calculator, shown for research reference only:

ERR agonist / exercise mimetic studied preclinically; values illustrative only.

Research reference only — not dosing guidance for human use. Use the calculator for other vials or volumes.

Supplied as a lyophilized powder. Store at 2–8 °C on receipt; protect from heat, light and moisture, and avoid excessive agitation. If reconstitution is required for laboratory work, use sterile technique — bacteriostatic water, or 0.6% acetic acid for low-solubility peptides. Protocols vary by research application.