SLU-PP-332

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 5 mg per vial
SKU: 322-5

Product Overview

SLU-PP-332 (a.k.a. SLU-PP-332) is a potent synthetic pan-agonist of Estrogen-Related Receptors alpha, beta, and gamma (ERRα/β/γ) — orphan nuclear receptors in the nuclear receptor superfamily that lack known endogenous ligands but play critical roles in regulating oxidative metabolism, mitochondrial biogenesis, and energy homeostasis in high-energy tissues including heart, skeletal muscle, and brown adipose tissue.

SLU-PP-332 binds to and activates all three ERR isoforms simultaneously, triggering transcriptional programs that upregulate PGC-1α-dependent mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation pathways. In preclinical studies, SLU-PP-332 produced remarkable exercise-mimetic effects including significant increases in running endurance (70% improvement in mice) and demonstrated therapeutic potential in heart failure models by restoring cardiac metabolic function and reducing pathological cardiac remodeling.

Research Applications

SLU-PP-332 has been examined in experimental studies related to:

• ERRα/β/γ nuclear receptor pan-agonism and transcriptional studies
• PGC-1α upregulation and mitochondrial biogenesis research
• Exercise mimicry and endurance performance models
• Heart failure metabolic rescue and cardiac remodeling studies
• Fatty acid oxidation and oxidative phosphorylation in muscle research
• Comparison with other nuclear receptor agonists (PPARs, LXR)

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.