VIP

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: VIP10

Product Overview

VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily, expressed in neurons of both the central and peripheral nervous systems as well as in immune cells and intestinal mucosa. It acts on two G-protein coupled receptors, VPAC1 (high expression in brain, intestine, and immune cells) and VPAC2 (expression in smooth muscle and brain), both signaling through cAMP/PKA pathways.

VIP exerts a wide range of regulatory effects: it is a potent vasodilator and bronchodilator in the pulmonary and gastrointestinal systems, modulates circadian rhythm timing through the suprachiasmatic nucleus (SCN), and demonstrates significant anti-inflammatory activity by suppressing TNF-α, IL-6, and IL-12 production while stimulating IL-10. It is studied in models of autoimmunity, neuroinflammation, pulmonary disease, and gastrointestinal physiology.

Research Applications

VIP has been examined in experimental studies related to:

• VPAC1/VPAC2 receptor pharmacology and cAMP signaling studies
• Anti-inflammatory cytokine (TNF-α, IL-6, IL-10) modulation research
• Circadian rhythm SCN modulation and chronobiology studies
• Pulmonary vasodilation and bronchodilatory research models
• Autoimmune and neuroinflammatory disease models
• Gastrointestinal motility and secretion research

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.