VIP

VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily, expressed in neurons of both the central and peripheral nervous systems as well as in immune cells and intestinal mucosa. It acts on two G-protein coupled receptors, VPAC1 (high expression in brain, intestine, and immune cells) and VPAC2 (expression in smooth muscle and brain), both signaling through cAMP/PKA pathways.

VIP exerts a wide range of regulatory effects: it is a potent vasodilator and bronchodilator in the pulmonary and gastrointestinal systems, modulates circadian rhythm timing through the suprachiasmatic nucleus (SCN), and demonstrates significant anti-inflammatory activity by suppressing TNF-α, IL-6, and IL-12 production while stimulating IL-10. It is studied in models of autoimmunity, neuroinflammation, pulmonary disease, and gastrointestinal physiology.

• VPAC1/VPAC2 receptor pharmacology and cAMP signaling studies
• Anti-inflammatory cytokine (TNF-α, IL-6, IL-10) modulation research
• Circadian rhythm SCN modulation and chronobiology studies
• Pulmonary vasodilation and bronchodilatory research models
• Autoimmune and neuroinflammatory disease models
• Gastrointestinal motility and secretion research

Dose levels referenced by the MVLabs peptide calculator, shown for research reference only:

Vasoactive intestinal peptide, often studied intranasally due to short half-life.

Research reference only — not dosing guidance for human use. Use the calculator for other vials or volumes.

Supplied as a lyophilized powder. Store at 2–8 °C on receipt; protect from heat, light and moisture, and avoid excessive agitation. If reconstitution is required for laboratory work, use sterile technique — bacteriostatic water, or 0.6% acetic acid for low-solubility peptides. Protocols vary by research application.