Snap-8

Snap-8 (Acetyl Glutamyl Heptapeptide-3, SNAP-8) is a synthetic octapeptide analog of the N-terminal domain of SNAP-25 (synaptosomal-associated protein of 25 kDa), one of the three core proteins of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor) complex that mediates calcium-triggered neurotransmitter vesicle fusion at synaptic junctions.

By presenting a competing peptide that mirrors the SNAP-25 N-terminal domain, Snap-8 interferes with SNARE complex assembly, reducing the efficiency of acetylcholine-containing vesicle fusion at neuromuscular junctions. In cosmetic research, this translates to studied modulation of facial muscle contraction intensity. It has a longer chain than Argireline (Acetyl Hexapeptide-3) and is studied for potentially broader SNARE complex interference in neuromuscular junction pharmacology.

• SNARE complex assembly interference and neuromuscular junction pharmacology
• Acetylcholine vesicle fusion modulation at synaptic terminals
• Comparison with Argireline (Acetyl Hexapeptide-3) mechanism studies
• Topical cosmetic anti-wrinkle and myorelaxant research
• SNAP-25 protein interaction and synaptic biology research
• Facial muscle contraction modulation in aesthetic dermatology research

Dose levels referenced by the MVLabs peptide calculator, shown for research reference only:

Cosmetic octapeptide used topically in serum formulations, not reconstituted for injection.

Research reference only — not dosing guidance for human use. Use the calculator for other vials or volumes.

Supplied as a lyophilized powder. Store at 2–8 °C on receipt; protect from heat, light and moisture, and avoid excessive agitation. If reconstitution is required for laboratory work, use sterile technique — bacteriostatic water, or 0.6% acetic acid for low-solubility peptides. Protocols vary by research application.