Melanotan I

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: MT1

Product Overview

Melanotan I (afamelanotide) is a synthetic tridecapeptide analog of α-melanocyte-stimulating hormone (α-MSH) in which a linear, non-cyclic structure is maintained. The primary modification over native α-MSH is substitution of Nle4 (norleucine) and D-Phe7, which confer metabolic stability and enhanced potency at melanocortin receptors.

Melanotan I acts preferentially at MC1R (melanocortin-1 receptor) on melanocytes, stimulating the switch from phaeomelanin (reddish-yellow, UV-sensitive pigment) to eumelanin (brown-black, UV-protective pigment) production. It is FDA-approved (as Scenesse implant, by Clinuvel Pharmaceuticals) for erythropoietic protoporphyria (EPP), a rare photosensitivity disorder, representing the first approved alpha-MSH analog. It is studied in photoprotection, melanocyte biology, and UV damage protection research.

Research Applications

Melanotan I has been examined in experimental studies related to:

• MC1R (melanocortin-1 receptor) pharmacology and receptor selectivity
• Eumelanin vs phaeomelanin switching and melanogenesis research
• Photoprotection and UV-induced DNA damage prevention models
• Erythropoietic protoporphyria (EPP) and photosensitivity research
• Melanocyte biology and pigmentation regulation studies
• Comparison with Melanotan II and alpha-MSH receptor selectivity

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.