PT-141

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: P41

Product Overview

PT-141 (Bremelanotide, formerly referred to as PT-141 in development) is a cyclic heptapeptide melanocortin receptor agonist derived from Melanotan II through removal of the C-terminal amide group and structural optimization. It is the active metabolite of Melanotan II following metabolic processing and acts primarily on MC3R and MC4R, which are expressed centrally in the hypothalamus, brainstem, and spinal cord.

Unlike PDE5 inhibitors (sildenafil, tadalafil) that work through vascular mechanisms, PT-141 activates pro-erectile and pro-sexual arousal neural pathways centrally. It is FDA-approved as Vyleesi (bremelanotide injection) for hypoactive sexual desire disorder (HSDD) in premenopausal women — the first approved centrally acting drug for a female sexual dysfunction. Research applications include central neural pathways of sexual arousal, melanocortin system behavioral pharmacology, and comparative studies with PDE5 inhibitors.

Research Applications

PT-141 has been examined in experimental studies related to:

• MC3R/MC4R central nervous system pharmacology and behavioral effects
• Neural pathways of sexual arousal, desire, and motivation research
• Comparison with PDE5 inhibitors: central vs peripheral mechanisms
• Hypoactive sexual desire disorder (HSDD) preclinical models
• Hypothalamic melanocortin system and feeding/sexual behavior integration
• Female sexual dysfunction pharmacology research

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.