Sermorelin

Sermorelin is a synthetic analog of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH 1-29-NH2). It is the shortest fully active fragment of GHRH capable of binding to pituitary GHRH receptors and stimulating GH secretion through physiological feedback mechanisms of the hypothalamic-pituitary axis.

Unlike exogenous GH administration, sermorelin acts by stimulating the pituitary gland itself to produce and secrete GH, preserving the natural negative feedback loops that regulate GH levels. This property makes it a valuable tool in research examining age-related GH decline, GH deficiency models, and the pharmacodynamics of pituitary GH secretion.

• Pituitary GHRH receptor stimulation and GH secretion studies
• Preservation of hypothalamic-pituitary feedback mechanism research
• Age-related GH decline and GH deficiency models
• Pharmacodynamics of pulsatile GH secretion research
• Comparison of sermorelin with synthetic GHRH analogs (CJC-1295, tesamorelin)
• IGF-1 axis response to physiological GH stimulation

Dose levels referenced by the MVLabs peptide calculator, shown for research reference only:

GHRH peptide. Best before sleep on an empty stomach.

Research reference only — not dosing guidance for human use. Use the calculator for other vials or volumes.

Supplied as a lyophilized powder. Store at 2–8 °C on receipt; protect from heat, light and moisture, and avoid excessive agitation. If reconstitution is required for laboratory work, use sterile technique — bacteriostatic water, or 0.6% acetic acid for low-solubility peptides. Protocols vary by research application.