KissPeptin-10

KissPeptin-10 (Kp-10) is the shortest bioactive fragment of the kisspeptin family — a group of peptide hormones encoded by the KISS1 gene that range from Kp-10 to Kp-54 in length. It acts as the endogenous ligand for the kisspeptin receptor (KISS1R, also called GPR54), a Gq/11-coupled receptor expressed in hypothalamic GnRH neurons and in peripheral reproductive tissues.

The kisspeptin/KISS1R system represents the primary gating mechanism controlling GnRH pulse secretion from the hypothalamus, effectively functioning as the "master switch" of reproductive physiology. Research applications include the study of GnRH pulse generation, puberty onset mechanisms, sex steroid negative/positive feedback, and gonadotropin secretion in normal and pathological reproductive states.

• KISS1R (GPR54) receptor pharmacology and Gq/11 signaling studies
• GnRH pulse generation and hypothalamic control mechanisms
• Puberty onset, pubertal delay, and precocious puberty research
• Sex steroid feedback regulation and neuroendocrinology
• Fertility, hypogonadism, and anovulation research models
• LH/FSH secretion dynamics and gonadotropin axis research

Dose levels referenced by the MVLabs peptide calculator, shown for research reference only:

HPG-axis signaling peptide. Research dosing is protocol-specific; values are illustrative.

Research reference only — not dosing guidance for human use. Use the calculator for other vials or volumes.

Supplied as a lyophilized powder. Store at 2–8 °C on receipt; protect from heat, light and moisture, and avoid excessive agitation. If reconstitution is required for laboratory work, use sterile technique — bacteriostatic water, or 0.6% acetic acid for low-solubility peptides. Protocols vary by research application.