Melanotan II

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 10 mg per vial
SKU: ML10

Product Overview

Melanotan II is a synthetic cyclic lactam analog of α-MSH (cyclo[Nle4, Asp5, D-Phe7, Lys10]-α-MSH-(4-10)). The cyclic structure confers significantly greater metabolic stability and potency than linear analogs. Unlike Melanotan I, Melanotan II is a non-selective melanocortin receptor agonist with substantial activity at MC1R, MC3R, MC4R, and MC5R.

Its broad receptor profile — particularly at MC4R, which is expressed in the hypothalamus, brainstem, and spinal cord — produces effects beyond melanogenesis, including appetite suppression, sexual arousal (erection in males via spinal MC4R), and increased energy expenditure. The MC4R-activating properties were the basis for development of PT-141 (bremelanotide), which retains the MC4R activity without the tanning effect. Melanotan II is studied in melanocortin pharmacology, sexual function research, and feeding behavior models.

Research Applications

Melanotan II has been examined in experimental studies related to:

• Broad melanocortin receptor (MC1R, MC3R, MC4R, MC5R) pharmacology
• UV-independent melanogenesis and eumelanin production research
• MC4R-mediated appetite suppression and energy expenditure studies
• Sexual arousal and spinal MC4R pharmacology models
• Comparison with Melanotan I, PT-141, and alpha-MSH receptor selectivity
• Feeding behavior, obesity, and hypothalamic melanocortin research

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.