Mots-c

MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c) is a 16-amino acid mitochondria-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome — making it one of a rare class of peptides encoded by mitochondrial rather than nuclear DNA.

MOTS-c acts as a metabolic regulator through AMPK (AMP-activated protein kinase) activation, enhancing glucose uptake in skeletal muscle, improving insulin sensitivity, and promoting mitochondrial homeostasis. Remarkably, plasma MOTS-c levels have been found to be significantly higher in long-lived individuals in human studies, and exercise increases MOTS-c production, suggesting it may function as a mitokine mediating exercise-related metabolic benefits.

• Mitochondria-derived peptide (MDP) signaling and biology
• AMPK activation and skeletal muscle glucose uptake studies
• Exercise mimicry and endurance metabolism research
• Insulin sensitivity and metabolic disease models
• Mitokine signaling between mitochondria and systemic tissues
• Aging and longevity biomarker research

Dose levels referenced by the MVLabs peptide calculator, shown for research reference only:

Mitochondrial peptide. Supports mitochondrial function and insulin sensitivity.

Research reference only — not dosing guidance for human use. Use the calculator for other vials or volumes.

Supplied as a lyophilized powder. Store at 2–8 °C on receipt; protect from heat, light and moisture, and avoid excessive agitation. If reconstitution is required for laboratory work, use sterile technique — bacteriostatic water, or 0.6% acetic acid for low-solubility peptides. Protocols vary by research application.