Selank

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a stabilized and bioavailable analog of the immunomodulatory tetrapeptide Tuftsin (Thr-Lys-Pro-Arg). It was designed with a Pro-Gly-Pro tripeptide extension that significantly extends its half-life compared to native Tuftsin.

Selank is registered as an anxiolytic drug in Russia and Ukraine (as a nasal spray) and has been extensively studied for its ability to reduce anxiety without the sedation, tolerance, or dependence associated with benzodiazepines. Its mechanisms include modulation of BDNF expression, enhancement of serotonin and dopamine metabolism, and reduction of IL-6 expression. It also retains the immunomodulatory properties of Tuftsin through T-cell and NK cell activity regulation.

• Anxiolytic activity without sedation or tolerance development
• BDNF expression upregulation and neuroprotective research
• Serotonin and dopamine metabolism modulation studies
• Tuftsin-analog immunomodulation and T-cell research
• Memory consolidation and cognitive enhancement models
• Comparison with benzodiazepines and other anxiolytics

Dose levels referenced by the MVLabs peptide calculator, shown for research reference only:

Anxiolytic nootropic. Subcutaneous or intranasal. 10–14 day cycles.

Research reference only — not dosing guidance for human use. Use the calculator for other vials or volumes.

Supplied as a lyophilized powder. Store at 2–8 °C on receipt; protect from heat, light and moisture, and avoid excessive agitation. If reconstitution is required for laboratory work, use sterile technique — bacteriostatic water, or 0.6% acetic acid for low-solubility peptides. Protocols vary by research application.