L-Glutathione

Purity: ≥99% HPLC
Format: Lyophilized powder
Quantity: 1500 mg per vial
SKU: GTT

Product Overview

L-Glutathione (GSH, γ-glutamylcysteinylglycine) is the most abundant non-protein thiol antioxidant in mammalian cells, present at millimolar concentrations in virtually all cell types. It is a tripeptide synthesized from L-glutamate, L-cysteine, and glycine through sequential enzymatic reactions catalyzed by γ-glutamylcysteine synthetase (GCS, rate-limiting step) and glutathione synthetase.

GSH functions as both a direct antioxidant (donating electrons to neutralize reactive oxygen and nitrogen species) and as the required substrate for glutathione peroxidase (GPx) enzymes in the detoxification of hydrogen peroxide and lipid hydroperoxides. It also participates in phase II xenobiotic detoxification through glutathione S-transferase (GST) conjugation reactions in the liver. In research applications, GSH is studied in cellular redox biology, skin pigmentation (inhibition of DOPA to melanin conversion), immune cell function, and mitochondrial health.

Research Applications

L-Glutathione has been examined in experimental studies related to:

• Cellular redox homeostasis and glutathione cycle research
• Glutathione peroxidase (GPx) and ROS neutralization studies
• Hepatic phase II xenobiotic detoxification (GST conjugation) research
• Melanin synthesis inhibition and skin pigmentation research
• Immune cell (lymphocyte, NK cell) function and redox regulation
• Mitochondrial antioxidant defense and electron transport chain protection

Handling and Storage (Laboratory Guidance)

This product is supplied as a lyophilized peptide powder.

Typical laboratory handling recommendations include:

• Store at 2–8 °C upon receipt.
• Protect from heat, moisture, and direct light.
• Avoid excessive agitation of the solution to maintain peptide stability.
• Reconstitution, if required for laboratory experiments, should be performed using appropriate sterile laboratory techniques.
• Use of acetic acid water (0.6%) or sterile bacteriostatic water is recommended for peptides with low aqueous solubility.

For reconstitution, CLICK HERE to use the PEPTIDE CALCULATOR

Laboratory protocols may vary depending on the specific research application.

Quality Information

• Research grade material
• High purity (≥99%)
• Lyophilized for stability
• Intended for controlled laboratory environments

Documentation such as analytical data or certificates of analysis may be available depending on the supplier.

Important Disclaimer – Research Use Only

This product is provided strictly for laboratory research and analytical purposes.

It is not intended for human or animal consumption.

This compound: is not a drug, is not a dietary supplement, and has not been approved by regulatory authorities such as the FDA, EMA, or other agencies for medical use.

The purchaser agrees that the product will be handled only by qualified professionals in appropriate research facilities and in accordance with all applicable laws and regulations. The supplier assumes no liability for misuse or improper handling of this material.